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Muscle Regeneration

January 12, 2012

Researchers have used reprogrammed human cells to create new muscle tissue in mice.



Regrowing muscle… I’m Bob Hirshon and this is Science Update.

Our muscles can patch minor wounds, but with a major injury, scarring blocks the replacement of lost tissue.  Now, researchers at Worcester Polytechnic Institute and the CellThera company in Massachusetts may have found a way around that.  Chris Malcuit of CellThera explains.

CHRIS MALCUIT (CellThera, Worcester, MA):

We found a new material called fibrin microthreads, which serve as a very nice delivery vehicle for putting new muscle cells into a wound site.  And at the same time, these microthreads cause a dramatic decrease in scar formation.


His team implanted the microthreads in mice with major muscle injuries.  Surprisingly, although the threads were seeded with human cells, the resulting muscles were composed mainly of mouse cells – suggesting the threads attracted the host’s own cells to rebuild new tissue. I’m Bob Hirshon for AAAS, the Science Society.